Novel Mechanism of Activation of NADPH Oxidase 5

Mechanism of Ca Activation of the NADPH Oxidase 5 (NOX5)*□S

From the Department of Biochemistry, University of Geneva, CH-1211 Genève, Switzerland, ‡Department of Geriatrics, Geneva University Hospitals, CH-1225 Genève, Switzerland, **Department of Physiology, Semmelweis University, H-1088 Budapest, Hungary, §Inflammation Program and Departments of Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, Iowa 52242, and ¶Depar...

Mechanism of Endothelial Cell NADPH Oxidase Activation by Angiotensin II

Endothelial cells express a constitutively active phagocyte-type NADPH oxidase whose activity is augmented by agonists such as angiotensin II. We recently reported (Li, J.-M., and Shah, A. M. (2002) J. Biol. Chem. 277, 19952–19960) that in contrast to neutrophils a substantial proportion of the NADPH oxidase in unstimulated endothelial cells exists as preassembled intracellular complexes. Here,...

Involvement of Activation of Nadph Oxidase

ABSTRACT Zinc is employed as a supplement; however, zinc-related nephropathy is not generally known. In this study, we investigatecl zinc-induced renal cell iajury using a pig kidney-derived cultured renal epithelial cell line, LLC-PKI, with proximal kidney tubule-like features, and examined the involvement of free radicals and extracellular signal-regu]ated kinase (ERK) in the cell injury. The...

During Phagocytosis NADPH Oxidase Activation and Assembly

Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit.

Endothelial cells express a constitutively active phagocyte-type NADPH oxidase whose activity is augmented by agonists such as angiotensin II. We recently reported (Li, J.-M., and Shah, A. M. (2002) J. Biol. Chem. 277, 19952-19960) that in contrast to neutrophils a substantial proportion of the NADPH oxidase in unstimulated endothelial cells exists as preassembled intracellular complexes. Here,...